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An endogenous caspase-11 ligand elicits interleukin-1 release from living dendritic cells.
Zanoni I, Tan Y, Di Gioia M, Broggi A, Ruan J, Shi J, Donado C, Shao F, Wu H, Springstead  J, Kagan J. 
Science, 2016 June 3; 352 (6290):1232-6.
PMID: 27103670

Hepititas C virus NS3-4A inhibits the peroxisomal MAVS-dependent antiviral signalling response. 
Ferreira AR, Magalhaes AC, Camoes F, Gouveia A, Vieira M, Kagan JC, Ribeiro D. 
J. Cell. Mol. Med., 2016; 4: 750-757.
PMID: 26865163

A single bacteria immune evasion strategy dismantles both MyD88 and TRIF signaling pathways downstrean of TLR4.
Rosadini CV, Zanoni I, Odendall C, Green ER, Paczosa MK, Phillip NH, Brodsky IE, Mecsas J, Kagan JC. 
Cell Host Microbe, 2015 Dec 9; 18 (6):682-93.
PMID: 26651944

PRRs are watching you: Localization of innate immune sensing and signaling regulators.
Chow J, Franz KM, Kagan JC. 
Virology. 2015 Mar 20; advance online publication.
PMID: 25800355

The unique regulation and functions of type III interferons in antiviral immunity.
Odendall C, Kagan JC. 
Curr Opin Virol. 2015 Mar 12; 12:47-52.
PMID: 25771505

Microbial strategies for antagonizing toll-like receptor signal transduction.
Rosadini CV, Kagan JC. 
Curr Opin Immunol. 2015 Jan 20; advance online publication.
PMID: 25615700

Innate immune pattern recognition: a cell biological perspective.
Brubaker SW, Bonham KS, Zanoni I, Kagan JC. 
Annu Rev Immunol. 2015 Jan 2; advance online publication.
PMID: 25581309

Emerging principles governing signal transduction by pattern-recognition receptors.
Kagan JC, Barton GM.
Cold Spring Harb Perspect Biol. 2014 Nov 13; advance online publication.
PMID: 25395297

SMOCs: supramolecular organizing centres that control innate immunity.
Kagan JC, Magupalli VG, Wu H.
Nat Rev Immunol. 2014 Oct 31; Epub.
PMID: 25359439

Common mechanisms activate plant guard receptors and TLR4.
Kagan JC.
Trends Immunol. 2014 Sep 12; S1471-4906(14):00153-7.
PMID: 25224694

Late endosomal trafficking of alternative serotype adenovirus vaccine vectors augments antiviral innate immunity.
Teigler JE, Kagan JC, Barouch DH. 
J Virol. 2014 Sep 15; 88(18):10354-63.
PMID: 24991003
Diverse intracellular pathogens activate type III interferon expression from peroxisomes.
Odendall C, Dixit E, Stavru F, Bierne H, Franz K, Durbin AF, Boulant S, Gehrke L, Cossart P, Kagan JC.
Nat Immunol. 2014 Jun 22; 15(8):717-26. 
PMID: 24952503
Endosomes as platforms for NOD-like receptor signaling.
Bonham KS, Kagan JC.
Cell Host & Microbe. 2014 May 14;15(5):523-5.
PMID: 24832447
A cross-disciplinary perspective on the innate immune responses to bacterial lipopolysaccharide.
Tan Y, Kagan JC.
Mol Cell. 2014 Apr 24;54(2):212-223.
PMID: 24766885
A bicistronic MAVS transcript highlights a class of truncated variants in antiviral immunity.
Brubaker SW, Gauthier AE, Mills EW, Ingolia NT, Kagan JC.
Cell. 2014 Feb 13;156(4):800-11.
PMID: 24529381
A promiscuous lipid-binding protein diversifies the subcellular sites of Toll-like receptor signal transduction.
Bonham KS, Orzalli MH, Hayashi K, Wolf AI, Glanemann C, Weninger W, Iwasaki A, Knipe DM, Kagan JC.
Cell. 2014 Feb 13;156(4):705-16.
PMID: 24529375
Sensing endotoxins from within.
Kagan JC.
Science. 2013;341:1184-1185.
PMID: 24031006
NLRP3 inflammasome activation: CD36 serves double duty.
Kagan JC, Horng T. 
Nat Immunol. 2013 Aug;14(8):772-4.
PMID: 23867926
Peroxisomes and the antiviral responses of Mammalian cells.
Odendall C, Kagan JC.
Subcell Biochem. 2013;69:67-75.
PMID: 23821143
Intracellular pathogen detection by RIG-I-like receptors.
Dixit E, Kagan JC.
Adv Immunol. 2013;117:99-125.
PMID: 23611287
Signaling organelles of the innate immune system.
Kagan JC.
Cell. 2012 Dec;151(6):1168-78.
PMID: 23217704
Defining the subcellular sites of innate immune signal transduction.
Kagan JC.
Trends Immunol. 2012 Sep;33(9):442-8.
PMID: 22817912
Phagosome as the organelle linking innate and adaptive immunity.
Kagan JC, Iwasaki A.
Traffic. 2012 Aug;13(8):1053-61.
PMID: 22577865
Phosphoinositide binding by the Toll adaptor dMyD88 controls antibacterial responses in Drosophila.
Marek LR, Kagan JC.
Immunity. 2012 Apr 20;36(4):612-22.
PMID:22464168
CD14 controls the LPS-induced endocytosis of Toll-like receptor 4.
Zanoni I, Ostuni R, Marek LR, Barresi S, Barbalat R, Barton GM, Granucci F, Kagan JC.
Cell. 2011 Nov 11;147(4):868-80.
PMID: 22078883
Deciphering the function of nucleic acid sensing TLRs one regulatory step at a time.
Marek LR, Kagan JC.
Front Biosci. 2011 Jun 1;16:2060-8. Review.
PMID: 21622162
Recycling endosomes and TLR signaling--the Rab11 GTPase leads the way.
Kagan JC.
Immunity. 2010 Oct 29;33(4):578-80.
PMID: 21029967
Peroxisomes are signaling platforms for antiviral innate immunity.
Dixit E, Boulant S, Zhang Y, Lee AS, Odendall C, Shum B, Hacohen N, Chen ZJ, Whelan SP, Fransen M, Nibert ML, Superti-Furga G, Kagan JC.
Cell. 2010 May 14;141(4):668-81.
PMID: 20451243
"Complementing" toll signaling.
Kagan JC.
Sci Signal. 2010 May 4;3(120)
PMID:20442416
A cell biological view of Toll-like receptor function: regulation through compartmentalization.
Barton GM, Kagan JC.
Nat Rev Immunol. 2009 Aug;9(8):535-42. Epub 2009 Jun 26. Review.
PMID: 19556980
TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta.
Kagan JC, Su T, Horng T, Chow A, Akira S, Medzhitov R.
Nat Immunol. 2008 Apr;9(4):361-8. Epub 2008 Feb 24.
PMID: 18297073