2025 

LPS binding caspase activation and recruitment domains (CARDs)are bipartite lipid binding modules. Cao AB, Devant P, Wang C, Sun M, Kennedy SN, Ma W, Ruan J, Kagan JC. Sci Adv. 2025 Mar 7;11(10):eadt9027. doi: 10.1126/sciadv.adt9027. Epub 2025 Mar 7.PMID: 40053584 

2024 

Molecular definition of the endogenous Toll-like receptor signalling pathways. Fisch D, Zhang T, Sun H, Ma W, Tan Y, Gygi SP, Higgins DE, Kagan JC. Nature. 2024 Jul;631(8021):635-644. doi: 10.1038/s41586-024-07614-7. Epub 2024 Jul 3.PMID: 38961291

pLxIS-containing domains are biochemically flexible regulators of interferons and metabolism. Landau LM, Chaudhary N, Tien YC, Rogozinska M, Joshi S, Yao C, Crowley J, Hullahalli K, Campbell IW, Waldor MK, Haigis M, Kagan JC. Mol Cell. 2024 Jul 11;84(13):2436-2454.e10. doi: 10.1016/j.molcel.2024.05.030. Epub 2024 Jun 25.PMID: 38925114

Correction of age-associated defects in dendritic cells enables CD4⁺ T cells to eradicate tumors. Zhivaki D, Kennedy SN, Park J, Boriello F, Devant P, Cao A, Bahleda KM, Murphy S, McCabe C, Evavold CL, Chapman KL, Zanoni I, Ashenberg O, Xavier RJ, Kagan JC. Cell. 2024 Jul 25;187(15):3888-3903.e18. doi: 10.1016/j.cell.2024.05.026. Epub 2024 Jun 12.PMID: 38870946

Waking the sleeping giant: Single-stranded DNA binds Schlafen 11 to initiate innate immune responses. Ragland SA, Kagan JC. Sci Immunol. 2024 Jun 14;9(96):eadp4474. doi: 10.1126/sciimmunol.adp4474. Epub 2024 Jun 14.PMID: 38875318

Strategies of bacterial detection by inflammasomes. Jastrab JB, Kagan JC. Cell Chem Biol. 2024 May 16;31(5):835-850. doi: 10.1016/j.chembiol.2024.03.009. Epub 2024 Apr 17.PMID: 38636521 

Publisher Correction: Structural insights into cytokine cleavage by inflammatory caspase-4. Devant P, Dong Y, Mintseris J, Ma W, Gygi SP, Wu H, Kagan JC. Nature. 2024 Jan;625(7995):E17. doi: 10.1038/s41586-023-06942-4.PMID: 38172642

2023

Structural insights into cytokine cleavage by inflammatory caspase-4. Devant P, Dong Y, Mintseris J, Ma W, Gygi SP, Wu H, Kagan JC. Nature. 2023 Dec;624(7991):451-459. doi: 10.1038/s41586-023-06751-9. Epub 2023 Nov 22.PMID: 37993712

mRNAs encoding self-DNA reactive cGAS enhance the immunogenicity of lipid nanoparticle vaccines. Zhivaki D, Gosselin EA, Sengupta D, Concepcion H, Arinze C, Chow J, Nikiforov A, Komoroski V, MacFarlane C, Sullivan C, Kagan JC. mBio. 2023 Dec 19;14(6):e0250623. doi: 10.1128/mbio.02506-23. Epub 2023 Nov 8.PMID: 37937842 

Targeting innate immune pathways for cancer immunotherapy. Cao LL, Kagan JC.Immunity. 2023 Oct 10;56(10):2206-2217. doi: 10.1016/j.immuni.2023.07.018. Epub 2023 Sep 12.PMID: 37703879 

Innate immunity decreases pathogen diversity during infection. Kagan JC. Proc Natl Acad Sci U S A. 2023 Oct 3;120(40):e2314237120. doi: 10.1073/pnas.2314237120. Epub 2023 Sep 20.PMID: 37729173

Beyond natural biology: rewiring cellular networks to study innate immunity. Landau LM, Kagan JC.Curr Opin Immunol. 2023 Aug;83:102349. doi: 10.1016/j.coi.2023.102349. Epub 2023 Jun 1.PMID: 37269786

Inflammasomes as regulators of non-infectious disease. Okin D, Kagan JC. Semin Immunol. 2023 Sep;69:101815. doi: 10.1016/j.smim.2023.101815. Epub 2023 Jul 26.PMID: 37506489 

Molecular mechanisms of gasdermin D pore-forming activity. Pascal Devant, Jonathan C Kagan, Nat Immunol. 2023 Jul; 24(7):1064-1075. doi: 10.1038/s41590-023-01526-w. Epub 2023 Jun 5. PMID: 37277654

Cold Spring Harbor Laboratory 2022: emerging insights and viewpoints in immunology. Kagan JC, Rothenberg EV, Weiss A, Rudensky AY, Smale ST.Trends Immunol. 2023 Apr;44(4):248-255. doi: 10.1016/j.it.2023.02.003. Epub 2023 Mar 11.PMID: 36907684 

Infection infidelities drive innate immunity.  Jonathan C Kagan, Science. 2023 Jan 27;379(6630):333-335. doi: 10.1126/science.ade9733. Epub 2023 Jan 26. PMID: 36701444

Excess lipids on endosomes dictates NLRP3 localization and inflammasome activation.  Jonathan C Kagan, Nat Immunol. 2023 Jan; 24(1):3-4. doi: 10.1038/s41590-022-01364-2. PMID: 36596890

Species-specific self-DNA detection mechanisms by mammalian cyclic GMP-AMP synthases. Kenta Mosallanejad, Stephanie N Kennedy, Kristin M Bahleda, Kailey M Slavik, Wen Zhou, Apurva A Govande, Dustin C Hancks, Philip J Kranzusch, Jonathan C Kagan, Sci Immunol. 2023 Jan 20;8(79):eabp9765. doi: 10.1126/sciimmunol.abp9765. Epub 2023 Jan 20. PMID: 36662885

Gasdermin D pore-forming activity is redox-sensitive.  Pascal Devant, Elvira Boršić, Elsy M Ngwa, Haopeng Xiao, Edward T Chouchani, Jay R Thiagarajah, Iva Hafner-Bratkovič, Charles L Evavold, Jonathan C Kagan, Cell Rep. 2023 Jan 31;42(1):112008. doi: 10.1016/j.celrep.2023.112008. Epub 2023 Jan 19. PMID: 36662620

2022

Legionella phagosomes intercept vesicular traffic from endoplasmic reticulum exit sites. Jonathan C Kagan, Craig R Roy, Nat Cell Biol. 2002 Dec;4(12):945-54. doi: 10.1038/ncb883. PMID: 12447391

Lipopolysaccharide detection by the innate immune system may be an uncommon defense strategy used in nature. Anna E Gauthier, Randi D Rotjan, Jonathan C Kagan, Open Biol. 2022 Oct;12(10):220146. doi: 10.1098/rsob.220146. Epub 2022 Oct 5. PMID: 36196535

Control of innate immunity by the cGAS-STING pathway. Kenta Mosallanejad, Jonathan C Kagan, Immunol Cell Biol. 2022 Jul;100(6):409-423. doi: 10.1111/imcb.12555. Epub 2022 May 25. PMID: 35485309

Diverse Control Mechanisms of the Interleukin-1 Cytokine Family. Charles L Evavold, Jonathan C Kagan, Front Cell Dev Biol. 2022 Jun 27;10:910983. doi: 10.3389/fcell.2022.910983. eCollection 2022. PMID: 35832789

Innate immune detection of lipid oxidation as a threat assessment strategy. Dania Zhivaki, Jonathan C Kagan, Nat Rev Immunol. 2022 May;22(5):322-330. doi: 10.1038/s41577-021-00618-8. Epub 2021 Sep 21. PMID: 34548649

Gasdermin Pore Forming Activities that Promote Inflammation from Living and Dead Cells. Anh Cao, Jonathan C Kagan, J Mol Biol. 2022 Feb 28;434(4):167427. doi: 10.1016/j.jmb.2021.167427. Epub 2021 Dec 29. PMID: 34973239

2021

NLRP3 inflammasomes that induce antitumor immunity. Dania Zhivaki, Jonathan C Kagan, Trends Immunol. 2021 Jul;42(7):575-589. doi: 10.1016/j.it.2021.05.001. Epub 2021 May 22. PMID: 34034975

Cytosolic detection of phagosomal bacteria-Mechanisms underlying PAMP exodus from the phagosome into the cytosol. Stephanie A Ragland, Jonathan C Kagan, Mol Microbiol. 2021 Dec;116(6):1420-1432. doi: 10.1111/mmi.14841. Epub 2021 Nov 22. PMID: 34738270

Evolution-inspired redesign of the LPS receptor caspase-4 into an interleukin-1β converting enzyme. Pascal Devant, Anh Cao, Jonathan C Kagan, Sci Immunol. 2021 Aug 10;6(62):eabh3567. doi: 10.1126/sciimmunol.abh3567. PMID: 34734155

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway. Charles L Evavold, Iva Hafner-Bratkovič, Pascal Devant, Jasmin M D’Andrea, Elsy M Ngwa, Elvira Boršić, John G Doench, Martin W LaFleur, Arlene H Sharpe, Jay R Thiagarajah, Jonathan C Kagan, Cell. 2021 Aug 19;184(17):4495-4511.e19. doi: 10.1016/j.cell.2021.06.028. Epub 2021 Jul 21. PMID: 34289345

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin-E-dependent pyroptosis in barrier epithelial cells. Megan H Orzalli, Aleksandra Prochera, Laurellee Payne, Avi Smith, Jonathan A Garlick, Jonathan C Kagan, Immunity. 2021 Jul 13;54(7):1447-1462.e5. doi: 10.1016/j.immuni.2021.04.012. Epub 2021 May 11. PMID: 33979579

Interferon-Independent Restriction of RNA Virus Entry and Replication by a Class of Damage-Associated Molecular Patterns. Michael J Ernandes, Jonathan C Kagan 2021, Apr 13;12(2):e00584-21. doi: 10.1128/mBio.00584-21. PMID: 33849978

Deep-sea microbes as tools to refine the rules of innate immune pattern recognition. Anna E Gauthier, Courtney E Chandler, Valentina Poli, Francesca M Gardner, Aranteiti Tekiau, Richard Smith, Kevin S Bonham, Erik E Cordes, Timothy M Shank, Ivan Zanoni, David R Goodlett, Steven J Biller, Robert K Ernst, Randi D Rotjan, Jonathan C Kagan, Sci Immunol. 2021 Mar 12;6(57):eabe0531. doi: 10.1126/sciimmunol.abe0531. PMID: 33712473

2020

Inflammasomes within Hyperactive Murine Dendritic Cells Stimulate Long-Lived T Cell-Mediated Anti-tumor Immunity. Zhivaki D, Borriello F, Chow OA, Doran B, Fleming I, Theisen DJ, Pallis P, Shalek AK, Sokol CL, Zanoni I, Kagan JC. Cell Rep. 2020 Nov 17; 33(7):108381. PMID: 33207188

Toll-like Receptors and the Control of Immunity. Fitzgerald KA, Kagan JC. Cell. 2020 Mar 19; 180(6):1044-1066. PMID: 32164908.

Lipids that directly regulate innate immune signal transduction. Barnett KC, Kagan JC. Innate Immun. 2020 Jan; 26(1):4-14. PMID: 31180799